Inhibition of the glycine decarboxylase multienzyme complex by the host-selective toxin victorin.

Identification of the 100-kD victorin binding protein from oats.

The fungus Cochliobolus victoriae, the causal agent of victoria blight of oats, produces the host-specific toxin victorin. Sensitivity of oats to victorin, and thus susceptibility to the fungus, is controlled by a single dominant gene. This gene is believed to also confer resistance to the crown rust pathogen Puccinia coronata. In the case of victoria blight, the gene has been hypothesized to c...

Victorin triggers programmed cell death and the defense response via interaction with a cell surface mediator.

The host-selective toxin victorin is produced by Cochliobolus victoriae, the causal agent of victoria blight of oats. Victorin has been shown to bind to the P protein of the glycine decarboxylase complex (GDC) in mitochondria, and induce defense-related responses such as phytoalexin synthesis, extracellular alkalization and programmed cell death. However, evidence demonstrating that the GDC pla...

Molecular Features Affecting the Biological Activity of the Host-Selective Toxins from Cochliobolus victoriae.

The structures of the toxins produced by Cochliobolus victoriae, victorin B, C, D, E, and victoricine, have recently been established. These toxins and modified forms of victorin C were tested for their effect on dark CO(2) fixation in susceptible oat (Avena sativa) leaf slices. Half-maximal inhibition of dark CO(2) fixation occurred with the native toxins in the range of 0.004 to 0.546 micromo...

H-Protein of the Glycine Decarboxylase Multienzyme Complex : Complementary DNA Encoding the Protein from Arabidopsis thaliana.

The glycine decarboxylase system: a fascinating complex.

The mitochondrial glycine decarboxylase multienzyme system, connected to serine hydroxymethyltransferase through a soluble pool of tetrahydrofolate, consists of four different component enzymes, the P-, H-, T- and L-proteins. In a multi-step reaction, it catalyses the rapid destruction of glycine molecules flooding out of the peroxisomes during the course of photorespiration. In green leaves, t...